Parkinson’s Disease (PD) causes motor impairment through α-synuclein (α-syn) overexpression. The discovery that a “Super Smeller” could detect PD through odor revolutionized diagnostic possibilities. Identifying volatile organic compounds (VOCs) responsible for this distinct PD odor could enable earlier, faster diagnosis. Previous studies identified specific VOCs correlating with PD odor. VOC breath analysis from mouse models with gut microbiomes that aggregate α-syn to identify additional volatile biomarkers linked to PD. This is an ongoing collaboration with Dr. Sarkis’s group from Caltech.