Discovering novel N acyl amides to bind to GPCRs

N acyl amides are a newly discovered lipid class that exists within both animals and humans. It has been previously studied that N-acyl amides can interact with GPCRs as either agonist or antagonists depending on what GPCRs are being looked at. From data collected from the American Gut paper which focused on gut samples taken from individuals different countries we were able to come up with predicted N acyl amide structures. We can use in silico docking predictions to test these proposed structures to come up with novel N acyl amides that can later be developed into GPCR agonists or antagonists.